Author: Lifeng Zhou; Arun Richard Chandrasekaran; Jibin Abraham Punnoose; Gaston Bonenfant; Stephon Charles; Oksana Levchenko; Pheonah Badu; Cassandra Cavaliere; Cara T. Pager; Ken Halvorsen
Title: Programmable low-cost DNA-based platform for viral RNA detection Document date: 2020_1_16
ID: 8kced06y_1
Snippet: Newly emerging or re-emerging viruses pose significant challenges to health care systems, particularly as globalization has contributed to the rampant spread of these viruses. 1 RNA viruses are frequently the cause of sweeping outbreaks due to the naturally high mutation rates during replication that lead to rapid viral evolution. 2, 3 Examples of this include the annual influenza outbreak, as well as more recent threats from Ebola virus, henipav.....
Document: Newly emerging or re-emerging viruses pose significant challenges to health care systems, particularly as globalization has contributed to the rampant spread of these viruses. 1 RNA viruses are frequently the cause of sweeping outbreaks due to the naturally high mutation rates during replication that lead to rapid viral evolution. 2, 3 Examples of this include the annual influenza outbreak, as well as more recent threats from Ebola virus, henipavirus, severe acute respiratory syndrome (SARS)-associated coronavirus, and Zika virus (ZIKV). Technological advancements in structural biology and genomics have been important for identifying viruses, and for advancing fundamental viral research and antiviral therapeutics. 4 However, clinical methods for robust, low-cost and rapid detection of viral infections optimized for use in low-resource areas and point-of-care (POC) mode remain a major challenge for emergent viruses.
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