Author: Ivan Mercurio; Vincenzo Tragni; Francesco Busco; Anna De Grassi; Ciro Leonardo Pierri
Title: Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies Document date: 2020_4_18
ID: mswmkgl4_60
Snippet: It was also possible to pose in the proposed molecular framework the recent proposed SARS-CoV-2 spike RBD directed CR3022 FAB antibody (6yla.pdb; 6w41.pdb, (62) A molecular framework like the ones here proposed will also help in studying the putative role of ACE inhibitors in perturbing ACE2-RBD interactions. Indeed, it was recently proposed that patients treated with ACE inhibitors might be more exposed to SARS-CoV-2 infection (70) . Although AC.....
Document: It was also possible to pose in the proposed molecular framework the recent proposed SARS-CoV-2 spike RBD directed CR3022 FAB antibody (6yla.pdb; 6w41.pdb, (62) A molecular framework like the ones here proposed will also help in studying the putative role of ACE inhibitors in perturbing ACE2-RBD interactions. Indeed, it was recently proposed that patients treated with ACE inhibitors might be more exposed to SARS-CoV-2 infection (70) . Although ACE1 (refseq accession number: NP_068576.1, representing the main target of ACE inhibitors) and ACE2 (NP_690043.1, testis isoform or NP_000780, somatic isoform, among the most studied isoforms)
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