Author: Yafei Wang; Randy Heiland; Morgan Craig; Courtney L. Davis; Ashlee N Ford Versypt; Adrianne Jenner; Jonathan Ozik; Nicholson Collier; Chase Cockrell; Andrew Becker; Gary An; James A. Glazier; Aarthi Narayanan; Amber M Smith; Paul Macklin
Title: Rapid community-driven development of a SARS-CoV-2 tissue simulator Document date: 2020_4_5
ID: lq4tcyh4_88
Snippet: PhysiCell is an open source simulation agent-based modeling framework for multicellular systems in 2D and 3D dynamical tissue environments 82 86 .) In this framework, each cell (of any type) is an off-lattice agent with independent cell cycle progression, death processes, volume changes, and mechanics-driven movement. Each cell agent can have independent data and models attached to it, allowing substantial flexibility in adapting the framework to.....
Document: PhysiCell is an open source simulation agent-based modeling framework for multicellular systems in 2D and 3D dynamical tissue environments 82 86 .) In this framework, each cell (of any type) is an off-lattice agent with independent cell cycle progression, death processes, volume changes, and mechanics-driven movement. Each cell agent can have independent data and models attached to it, allowing substantial flexibility in adapting the framework to problems in cancer biology, microbiology, tissue engineering, and other fields. PhysiCell is 9 coupled to BioFVM (an open source biological diffusion solver) 87 to simulate the chemical microenvironment; as part of this coupling, each individual agent can secrete or uptake diffusing substrates and track the total amount of material entering and leaving the cell.
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