Author: Juan Angel Patino-Galindo; Ioan Filip; Mohammed AlQuraishi; Raul Rabadan
Title: Recombination and lineage-specific mutations led to the emergence of SARS-CoV-2 Document date: 2020_2_18
ID: bgdcm1i1_32
Snippet: The evolutionary changes that occurred in the Spike gene in Sarbecoviruses, either at amino acid level or 4-fold degenerated sites, were traced using a continuous-time Markov chain model for ancestral state reconstruction implemented in the Ape R package 33 . As input, the ML tree derived from 3 rd codon positions at the RBD recombinant region was used. We then compared the distribution of synonymous and nonsynonymous substitutions along the bran.....
Document: The evolutionary changes that occurred in the Spike gene in Sarbecoviruses, either at amino acid level or 4-fold degenerated sites, were traced using a continuous-time Markov chain model for ancestral state reconstruction implemented in the Ape R package 33 . As input, the ML tree derived from 3 rd codon positions at the RBD recombinant region was used. We then compared the distribution of synonymous and nonsynonymous substitutions along the branch specific to SARS-CoV-2.
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