Author: Yueping Li; Zhiwei Xie; Weiyin Lin; Weiping Cai; Chunyan Wen; Yujuan Guan; Xiaoneng Mo; Jian Wang; Yaping Wang; Ping Peng; Xudan Chen; Wenxin Hong; Guangming Xiao; Jinxin Liu; Lieguang Zhang; Fengyu Hu; Feng Li; Feng Li; Fuchun Zhang; Xilong Deng; Linghua Li
Title: An exploratory randomized, controlled study on the efficacy and safety of lopinavir/ritonavir or arbidol treating adult patients hospitalized with mild/moderate COVID-19 (ELACOI) Document date: 2020_3_23
ID: 9hknw4ws_2
Snippet: Middle East respiratory syndrome (MERS) [ 3 ] . The World Health Organization (WHO) declared COVID-19 as a public health emergency of international concern and characterized the outbreak as a pandemic on March 12, 2020. As of March 31 st , 2020, 750,890 confirmed cases and 36,405 death cases have been documented globally [ 2 ] . Despite its rapid global spread, little is known about the pathogenesis of the virus or its infectious host. Even worse.....
Document: Middle East respiratory syndrome (MERS) [ 3 ] . The World Health Organization (WHO) declared COVID-19 as a public health emergency of international concern and characterized the outbreak as a pandemic on March 12, 2020. As of March 31 st , 2020, 750,890 confirmed cases and 36,405 death cases have been documented globally [ 2 ] . Despite its rapid global spread, little is known about the pathogenesis of the virus or its infectious host. Even worse, no vaccine or specific antiviral drugs have demonstrated efficacy in prevention or treatment of COVID-19, which has led to great difficulty in controlling the epidemic and decreasing the mortality rate inhibitor, usually combined with ritonavir to inhibit cytochrome P450 in order to increase the half-life of lopinavir [ 6 ] . In the past 10 years, LPV/r has been proven to have good efficacy and limited side effects for treating HIV-1 [7] .
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