An exploratory randomized, controlled study on the efficacy and safety of lopinavir/ritonavir or arbidol treating adult patients hospitalized with mild/moderate COVID-19 (ELACOI)

Yueping Li; Zhiwei Xie; Weiyin Lin; Weiping Cai; Chunyan Wen; Yujuan Guan; Xiaoneng Mo; Jian Wang; Yaping Wang; Ping Peng; Xudan Chen; Wenxin Hong; Guangming Xiao; Jinxin Liu; Lieguang Zhang; Fengyu Hu; Feng Li; Feng Li; Fuchun Zhang; Xilong Deng; Linghua Li

The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.19.20038984 doi: medRxiv preprint 0 1 0 All eligible participants were assigned a randomization number which allocated them into one treatment group. The randomization numbers were computer-generated. Allocation concealment was achieved using a centralized web-based randomization system in which the participant identifier (hospitalization number) was entered before the allocation was revealed. The randomization numbers were used in case report form (CRF) pages. The study was blinded to participants and those physicians and radiologists who reviewed the data and radiological images but open-label to clinicians who recruited patients and research staff. author/funder, who has granted medRxiv a license to display the preprint in perpetuity. PCR primer and probe sets, targeting ORF1ab (FAM reporter) and N (VIC reporter) genes separately, were added in the same reaction. Positive and negative controls were included for each batch. Samples were considered to be positive when either or both set(s) gave a reliable signal(s) [14] .