Author: Ramya Rangan; Ivan N. Zheludev; Rhiju Das
Title: RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses Document date: 2020_3_28
ID: kjeqdse5_25
Snippet: We believe a more thorough structure/function analysis of the virus should be obtainable with recent experimental technologies that integrate multidimensional chemical mapping, electron microscopy, and computer modeling. [31] [32] New candidates for structured RNA elements in SARS-CoV-2 could play various functional roles, perhaps regulating viral packaging, replication, RNA synthesis, or translation initiation. To further improve these structure.....
Document: We believe a more thorough structure/function analysis of the virus should be obtainable with recent experimental technologies that integrate multidimensional chemical mapping, electron microscopy, and computer modeling. [31] [32] New candidates for structured RNA elements in SARS-CoV-2 could play various functional roles, perhaps regulating viral packaging, replication, RNA synthesis, or translation initiation. To further improve these structure predictions, information about protein-binding events should be integrated, and biochemical assays can be conducted with these proteins present or even in cells. Accounting for protein-binding events will be critical to completing a picture of accessible and structured RNA sites.
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