Author: Ramya Rangan; Ivan N. Zheludev; Rhiju Das
Title: RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses Document date: 2020_3_28
ID: kjeqdse5_9
Snippet: The intrinsic RNA structure of a conserved genome region is of interest in current medical research (Fig. 1B) . On one hand, stable secondary structure domains are candidates for harboring stereotyped 3D RNA folds that present targets for small-molecule drug therapeutics. On the other hand, if an RNA region is sufficiently unstructured to allow binding by hybridization probes, antisense oligonucleotides may be used to disrupt these functional str.....
Document: The intrinsic RNA structure of a conserved genome region is of interest in current medical research (Fig. 1B) . On one hand, stable secondary structure domains are candidates for harboring stereotyped 3D RNA folds that present targets for small-molecule drug therapeutics. On the other hand, if an RNA region is sufficiently unstructured to allow binding by hybridization probes, antisense oligonucleotides may be used to disrupt these functional structures. Such unstructured stretches may also be more likely to be accessible to diagnostic and antiviral interventions including standard RT-PCR assays.
Search related documents:
Co phrase search for related documents- current medical research and medical research: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- current medical research and small molecule: 1
- drug therapeutic and genome region: 1
- drug therapeutic and medical research: 1, 2, 3
- drug therapeutic and present target: 1, 2, 3
- drug therapeutic and RT PCR assay: 1, 2
- drug therapeutic and secondary structure: 1
- drug therapeutic and small molecule: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- functional structure and genome region: 1
- functional structure and medical research: 1
- functional structure and RNA structure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- functional structure and secondary structure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- functional structure and small molecule: 1
- functional structure disrupt and secondary structure: 1, 2
- genome region and medical research: 1, 2
- genome region and present target: 1
- genome region and RNA region: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- genome region and RT PCR assay: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- genome region and secondary structure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
Co phrase search for related documents, hyperlinks ordered by date