Author: Chunyun Sun; Long Chen; Ji Yang; Chunxia Luo; Yanjing Zhang; Jing Li; Jiahui Yang; Jie Zhang; Liangzhi Xie
Title: SARS-CoV-2 and SARS-CoV Spike-RBD Structure and Receptor Binding Comparison and Potential Implications on Neutralizing Antibody and Vaccine Development Document date: 2020_2_20
ID: nhq0oq8y_3
Snippet: Neutralizing antibody (nAb) is expected to be one of the most promising treatments against coronavirus infection among the existing therapeutic options 20, 21 . Several nAbs targeting SARS-CoV exhibit significant in vivo antivirus activities by reducing virus titers in lung tissues of animal models [22] [23] [24] [25] [26] . However, coronavirus is a single-stranded RNA virus prone to rapid mutations during transmission, nAbs without cross-reacti.....
Document: Neutralizing antibody (nAb) is expected to be one of the most promising treatments against coronavirus infection among the existing therapeutic options 20, 21 . Several nAbs targeting SARS-CoV exhibit significant in vivo antivirus activities by reducing virus titers in lung tissues of animal models [22] [23] [24] [25] [26] . However, coronavirus is a single-stranded RNA virus prone to rapid mutations during transmission, nAbs without cross-reactivity to a broad spectrum of viral mutants could lead to treatment failure 10, [27] [28] [29] , therefore, highly potent and cross-protective nAbs and prophylactic vaccines against SARS-CoV-2 are in urgent needs.
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