Selected article for: "cellular receptor and host cell membrane"
Author: Ke Wang; Wei Chen; Yu-Sen Zhou; Jian-Qi Lian; Zheng Zhang; Peng Du; Li Gong; Yang Zhang; Hong-Yong Cui; Jie-Jie Geng; Bin Wang; Xiu-Xuan Sun; Chun-Fu Wang; Xu Yang; Peng Lin; Yong-Qiang Deng; Ding Wei; Xiang-Min Yang; Yu-Meng Zhu; Kui Zhang; Zhao-Hui Zheng; Jin-Lin Miao; Ting Guo; Ying Shi; Jun Zhang; Ling Fu; Qing-Yi Wang; Huijie Bian; Ping Zhu; Zhi-Nan Chen
Title: SARS-CoV-2 invades host cells via a novel route: CD147-spike protein
  • Document date: 2020_3_14
    • ID: 5hpbjkft_2
    Snippet: It has been reported that CoVs are non-segmented positive sense RNA viruses, which primarily cause enzootic infections in birds and mammals and have demonstrated strong lethality in humans [1, 2] . These viruses are known to have four structural proteins, including E, M, N and S protein [3, 4] . The primary determinant of CoVs tropism is the S protein, which binds to the membrane receptor on the host cells, mediating the viral and cellular membra.....
    Document: It has been reported that CoVs are non-segmented positive sense RNA viruses, which primarily cause enzootic infections in birds and mammals and have demonstrated strong lethality in humans [1, 2] . These viruses are known to have four structural proteins, including E, M, N and S protein [3, 4] . The primary determinant of CoVs tropism is the S protein, which binds to the membrane receptor on the host cells, mediating the viral and cellular membrane fusion [5] . Angiotensin-converting enzyme 2 (ACE2), a homologue of ACE, is one of the important receptors on the cell membrane of the host cells.

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