Author: Kumari G. Lokugamage; Adam Hage; Craig Schindewolf; Ricardo Rajsbaum; Vineet D. Menachery
Title: SARS-CoV-2 is sensitive to type I interferon pretreatment Document date: 2020_3_9
ID: 2w0zr9c0_41
Snippet: While IFN-I has been used in response to chronic viral infection (41), previous examination of 239 SARS-CoV cases found inconclusive effect for type I IFN treatment (42). However, the findings 240 from the SARS-CoV outbreak were complicated by combination therapy of type I IFN with other 241 treatments including ribavirin/steroids and lack of a regimented protocol. While type I IFN has 242 been utilized to treat MERS-CoV infected patients, no con.....
Document: While IFN-I has been used in response to chronic viral infection (41), previous examination of 239 SARS-CoV cases found inconclusive effect for type I IFN treatment (42). However, the findings 240 from the SARS-CoV outbreak were complicated by combination therapy of type I IFN with other 241 treatments including ribavirin/steroids and lack of a regimented protocol. While type I IFN has 242 been utilized to treat MERS-CoV infected patients, no conclusive data yet exists to determine 243 efficacy (43). Yet, in vivo studies with MERS-CoV has found that early induction with type I IFN 244
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