Selected article for: "endosomal membrane and ligase complex"
Author: Claude Pasquier; Alain Robichon
Title: SARS-CoV-2 might manipulate against its host the immunity RNAi/Dicer/Ago system Does mitochondria collapse upon COVID-19 infection?
  • Document date: 2020_4_9
    • ID: 7g8dmz57_23
    Snippet: Remarkably FBXO21 ubiquitin ligase complex has been reported to be required for antiviral innate The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.08.031856 doi: bioRxiv preprint response [19] . The host ubiquitin system is known to be crucial in innate immunity, the host E3-ubiquitin ligase having clearly antiviral functions [35] . In support of this, a viral protein (HBX) of hepatitis .....
    Document: Remarkably FBXO21 ubiquitin ligase complex has been reported to be required for antiviral innate The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.08.031856 doi: bioRxiv preprint response [19] . The host ubiquitin system is known to be crucial in innate immunity, the host E3-ubiquitin ligase having clearly antiviral functions [35] . In support of this, a viral protein (HBX) of hepatitis B (DNA virus) has been reported to interact with MAVS in inhibiting its action by promoting its ubiquitination [36] . Finally DNAJC13 is an endosome-related protein and believed to regulate endosomal membrane trafficking. Mutations provoke Parkinson disease and neurodegeneration [18] .

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