Author: Aran Singanayagam; Su-Ling Loo; Maria Calderazzo; Lydia J Finney; Maria-Belen Trujillo Torralbo; Eteri Bakhsoliani; Jason Girkin; Punnam Veerati; Prabuddha S Pathinayake; Kristy S Nichol; Andrew Reid; Joseph Foottit; Sebastian L Johnston; Nathan W Bartlett; Patrick Mallia
Title: Anti-microbial immunity is impaired in COPD patients with frequent exacerbations Document date: 2019_5_9
ID: 72jzqm86_3
Snippet: We hypothesised that patients with COPD who have a history of frequent exacerbations would have impaired anti-viral and/or anti-bacterial immunity compared to infrequent exacerbators. Using analysis of sputum samples from a cohort of patients monitored prospectively in the community, in combination with in vitro experiments in BECs sampled from patients with COPD and differentiated at the air-liquid interface (ALI), we show that lung innate anti-.....
Document: We hypothesised that patients with COPD who have a history of frequent exacerbations would have impaired anti-viral and/or anti-bacterial immunity compared to infrequent exacerbators. Using analysis of sputum samples from a cohort of patients monitored prospectively in the community, in combination with in vitro experiments in BECs sampled from patients with COPD and differentiated at the air-liquid interface (ALI), we show that lung innate anti-microbial immunity is impaired in frequent exacerbators. These mechanisms may underlie the increased propensity to exacerbation observed in some patients. author/funder. All rights reserved. No reuse allowed without permission.
Search related documents:
Co phrase search for related documents- air liquid and ALI air liquid interface differentiate: 1
- air liquid interface and ALI air liquid interface: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- air liquid interface and ALI air liquid interface differentiate: 1
Co phrase search for related documents, hyperlinks ordered by date