Selected article for: "HLA protein and molecular interaction"
Author: Neha Jain; Uma Shankar; Prativa Majee; Amit Kumar
Title: Scrutinizing the SARS-CoV-2 protein information for the designing an effective vaccine encompassing both the T-cell and B-cell epitopes
  • Document date: 2020_4_1
    • ID: lmstdmyb_53
    Snippet: MHC class I and class II alleles have a specific binding groove where the peptide binds and are presented on the cell surface for immune system activation. The protein structures of SAR-CoV-2 were modelled using I-Tasser (Supplementary Figure S1) . To check the molecular interaction of our selected CTL and HTL epitopes with their respective HLA alleles, we performed protein-protein docking using ClusPro. HLA alleles were taken as receptors and ep.....
    Document: MHC class I and class II alleles have a specific binding groove where the peptide binds and are presented on the cell surface for immune system activation. The protein structures of SAR-CoV-2 were modelled using I-Tasser (Supplementary Figure S1) . To check the molecular interaction of our selected CTL and HTL epitopes with their respective HLA alleles, we performed protein-protein docking using ClusPro. HLA alleles were taken as receptors and epitopes as ligands. ClusPro performs the interaction analysis by first generating billions of conformers eventually leading to rigid target based molecular docking.

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