Selected article for: "construct potential and immune response"
Author: Neha Jain; Uma Shankar; Prativa Majee; Amit Kumar
Title: Scrutinizing the SARS-CoV-2 protein information for the designing an effective vaccine encompassing both the T-cell and B-cell epitopes
  • Document date: 2020_4_1
    • ID: lmstdmyb_60
    Snippet: Upon analyzing the vaccine construct sequence in VaxiJen server, the constructed vaccine was found to be antigenic in nature with an overall prediction score of 0.6199. The score signifies the antigenic potential of the vaccine construct that may have the potential to evoke the immune response inside the host. On allergenicity analysis, all the three tools AlgPred, AllergenFP and AllerTop supported the non-allergenic nature of the vaccine constru.....
    Document: Upon analyzing the vaccine construct sequence in VaxiJen server, the constructed vaccine was found to be antigenic in nature with an overall prediction score of 0.6199. The score signifies the antigenic potential of the vaccine construct that may have the potential to evoke the immune response inside the host. On allergenicity analysis, all the three tools AlgPred, AllergenFP and AllerTop supported the non-allergenic nature of the vaccine construct while toxicity analysis revealed the non-toxic behavior of the construct ( Table 2 ). In summary, the constructed epitope was observed to be stable, soluble, antigenic, non-allergenic and nontoxic.

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