Author: Jacob Kames; David Dillon Holcomb; Ofer Kimchi; Michael DiCuccio; Nobuko Hamasaki-Katagiri; Tony Wang; Anton A Komar; Aikaterini Alexaki; Chava Kimchi-Sarfaty
Title: Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design Document date: 2020_3_31
ID: 2fn25l6m_11
Snippet: Since the mechanism of viral attenuation through codon pair deoptimization is not entirely clear, and it has been argued that it is an indirect result of increased CpG content, we further investigated the dinucleotide and junction dinucleotide profile of the SARS-CoV-2 as it compares with Homo sapiens genome and lung transcriptome ( Figure 3 ). Clearly, CpG dinucleotides are avoided in the SARS-CoV-2 genome, and to a lesser extent CC and GG dinuc.....
Document: Since the mechanism of viral attenuation through codon pair deoptimization is not entirely clear, and it has been argued that it is an indirect result of increased CpG content, we further investigated the dinucleotide and junction dinucleotide profile of the SARS-CoV-2 as it compares with Homo sapiens genome and lung transcriptome ( Figure 3 ). Clearly, CpG dinucleotides are avoided in the SARS-CoV-2 genome, and to a lesser extent CC and GG dinucleotides are too. This provides an opportunity to increase immunogenicity of a potential attenuated virus vaccine by increasing its CpG content.
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