Author: Bing-peng Lin; Mei Zhong; Hong-bin Gao; Kai-bin Wu; Ming-xiao Liu; Chang Liu; Xin-hong Wang; Jian-ming Chen; Learn-han Lee; Cui-ling Qi; Lin-hu Ge; Li-jing Wang
Title: Significant expression of FURIN and ACE2 on oral epithelial cells may facilitate the efficiency of 2019-nCov entry Document date: 2020_4_18
ID: 0vqzlurx_37
Snippet: In the current study, we investigated the expression of other endopeptidases in various oral mucosa cells using the public single-cell sequence datasets. As shown by voilin plot in supplemental files, the high expression of ACE2 sheddase, ADAM17, ADAM10 indicated the higher membrane fusion activity, virus uptake and virus replication in the oral mucosa. Besides, the endopeptidases (such as CAPN1 and CAPNS1) were abundantly enriched in the oral mu.....
Document: In the current study, we investigated the expression of other endopeptidases in various oral mucosa cells using the public single-cell sequence datasets. As shown by voilin plot in supplemental files, the high expression of ACE2 sheddase, ADAM17, ADAM10 indicated the higher membrane fusion activity, virus uptake and virus replication in the oral mucosa. Besides, the endopeptidases (such as CAPN1 and CAPNS1) were abundantly enriched in the oral mucosal cells. Large proportion of endopeptidases positive cells in the different oral sites provided opportunities for SARS-CoV-2 infection and rapid replication in the oral cavity [15] . These results were in accordance with the previous study, which indicated the residence of SARS-CoV-2 in nasal and throats swab samples, suggesting the strong spread ability in oral cavity [36] .
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