Selected article for: "previous study and single cell"
Author: Bing-peng Lin; Mei Zhong; Hong-bin Gao; Kai-bin Wu; Ming-xiao Liu; Chang Liu; Xin-hong Wang; Jian-ming Chen; Learn-han Lee; Cui-ling Qi; Lin-hu Ge; Li-jing Wang
Title: Significant expression of FURIN and ACE2 on oral epithelial cells may facilitate the efficiency of 2019-nCov entry
  • Document date: 2020_4_18
    • ID: 0vqzlurx_37
    Snippet: In the current study, we investigated the expression of other endopeptidases in various oral mucosa cells using the public single-cell sequence datasets. As shown by voilin plot in supplemental files, the high expression of ACE2 sheddase, ADAM17, ADAM10 indicated the higher membrane fusion activity, virus uptake and virus replication in the oral mucosa. Besides, the endopeptidases (such as CAPN1 and CAPNS1) were abundantly enriched in the oral mu.....
    Document: In the current study, we investigated the expression of other endopeptidases in various oral mucosa cells using the public single-cell sequence datasets. As shown by voilin plot in supplemental files, the high expression of ACE2 sheddase, ADAM17, ADAM10 indicated the higher membrane fusion activity, virus uptake and virus replication in the oral mucosa. Besides, the endopeptidases (such as CAPN1 and CAPNS1) were abundantly enriched in the oral mucosal cells. Large proportion of endopeptidases positive cells in the different oral sites provided opportunities for SARS-CoV-2 infection and rapid replication in the oral cavity [15] . These results were in accordance with the previous study, which indicated the residence of SARS-CoV-2 in nasal and throats swab samples, suggesting the strong spread ability in oral cavity [36] .

    Search related documents:
    Co phrase search for related documents
    • current study and high expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • current study and large proportion: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • current study and membrane fusion activity: 1, 2
    • current study and mucosal cell: 1, 2
    • current study and oral cavity: 1, 2, 3, 4
    • current study and oral mucosa: 1, 2, 3
    • current study and oral site: 1
    • current study and positive cell: 1, 2, 3, 4
    • current study and previous study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • different oral site and oral cavity: 1
    • different oral site and oral site: 1, 2
    • fusion activity and high expression: 1, 2
    • fusion activity and membrane fusion activity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • fusion activity and mucosa cell: 1
    • fusion activity and mucosal cell: 1, 2
    • fusion activity and oral cavity: 1
    • fusion activity and oral mucosa: 1
    • fusion activity and oral mucosa cell: 1
    • high expression and positive cell: 1, 2, 3, 4, 5, 6