Author: Allen Wang; Joshua A Chiou; Olivier B Poirion; Justin Buchanan; Michael J Valdez; Jamie M Verheyden; Xiaomeng Hou; Minzhe Guo; Jacklyn M Newsome; Parul Kudtarkar; Dina A Faddah; Kai Zhang; Randee E Young; Justinn Barr; Ravi Misra; Heidie Huyck; Lisa Rogers; Cory Poole; Jeffery A Whitsett; Gloria Pryhuber; Yan Xu; Kyle J Gaulton; Sebastian Preissl; Xin Sun
Title: Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection Document date: 2020_4_14
ID: 5kvq6jtx_30
Snippet: Furthermore, in fine-mapping data, rs35074065 had a high posterior probability 430 (PPA=41.6%) and therefore likely has a direct casual effect on TMPRSS2 expression 431 ( Figure 4D ). This variant further disrupted sequence motifs for IRF and STAT transcription 432 factors, suggesting that its effects may be mediated through interferon signaling and anti-433 viral programs ( Figure 4D ). 434.....
Document: Furthermore, in fine-mapping data, rs35074065 had a high posterior probability 430 (PPA=41.6%) and therefore likely has a direct casual effect on TMPRSS2 expression 431 ( Figure 4D ). This variant further disrupted sequence motifs for IRF and STAT transcription 432 factors, suggesting that its effects may be mediated through interferon signaling and anti-433 viral programs ( Figure 4D ). 434
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