Author: Wei Lin; Longfei Hu; Yan Zhang; Joshua D. Ooi; Ting Meng; Peng Jin; Xiang Ding; Longkai Peng; Lei Song; Zhou Xiao; Xiang Ao; Xiangcheng Xiao; Qiaoling Zhou; Ping Xiao; Jue Fan; Yong Zhong
Title: Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection Document date: 2020_2_18
ID: mm2sp48e_5
Snippet: We obtained the scRNA-Seq data of healthy bladder tissues of three bladder cancer patients from the Gene Expression Omnibus (GSE108097). To be consistent with the kidney datasets, we applied Harmony 14 to integrate samples and performed downstream analysis using Seurat V3. Clustering analysis was done by first reducing the gene expression matrix to the first 20 principal components and then using resolution 0.3 for the graph-based clustering. We .....
Document: We obtained the scRNA-Seq data of healthy bladder tissues of three bladder cancer patients from the Gene Expression Omnibus (GSE108097). To be consistent with the kidney datasets, we applied Harmony 14 to integrate samples and performed downstream analysis using Seurat V3. Clustering analysis was done by first reducing the gene expression matrix to the first 20 principal components and then using resolution 0.3 for the graph-based clustering. We annotated the cell types afresh using the canonical markers listed in the supplementary table of the original paper.
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