Author: Yasunori Watanabe; Joel D. Allen; Daniel Wrapp; Jason S. McLellan; Max Crispin
Title: Site-specific analysis of the SARS-CoV-2 glycan shield Document date: 2020_3_28
ID: 63j4qc7d_14
Snippet: Using the cryo-EM structure of the trimeric SARS-CoV-2 S protein (PDB ID 6VSB) 18 , we generated a model to map the glycosylation status of the coronavirus spike mimetic onto the experimentally determined 3D structure (Figure 3) . This combined mass spectrometric and cryo-EM analysis reveals how the N-linked glycans occlude distinct regions across the surface of the SARS-CoV-2 spike. Glycans were modelled onto each site using predominant glycans .....
Document: Using the cryo-EM structure of the trimeric SARS-CoV-2 S protein (PDB ID 6VSB) 18 , we generated a model to map the glycosylation status of the coronavirus spike mimetic onto the experimentally determined 3D structure (Figure 3) . This combined mass spectrometric and cryo-EM analysis reveals how the N-linked glycans occlude distinct regions across the surface of the SARS-CoV-2 spike. Glycans were modelled onto each site using predominant glycans observed (Figure 2) and colored according to the prevalence of oligomannose-type glycans.
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