Author: Anamika Basu; Anasua Sarkar; Ujjwal Maulik
Title: Strategies for vaccine design for corona virus using Immunoinformatics techniques Document date: 2020_3_2
ID: 618glydc_36
Snippet: The T cell epitope 76 PTDTYTSVYLGKFRG 90 (MHC II restricted) is selected on the basis of its interactions with large number of alleles and lowest IC50 value with HLA-DRB5*01:01 MHC II allele. Similarly, 76 PTDTYTSVY 84 , restricted with MHC I allelic protein HLA-A*01:01 is designated as most probable T cell epitope which is also present in conserved region of non-structural protein NS4 of coronavirus. Docking studies are performed with these two .....
Document: The T cell epitope 76 PTDTYTSVYLGKFRG 90 (MHC II restricted) is selected on the basis of its interactions with large number of alleles and lowest IC50 value with HLA-DRB5*01:01 MHC II allele. Similarly, 76 PTDTYTSVY 84 , restricted with MHC I allelic protein HLA-A*01:01 is designated as most probable T cell epitope which is also present in conserved region of non-structural protein NS4 of coronavirus. Docking studies are performed with these two epitopes with human HLA-DRB5*01:01MHC II molecule and MHC I allelic protein HLA-A*01:01 respectively.
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