Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_22
Snippet: 86.4 ± 5.4% parkin remaining, N = 5, p = 0.2 vs. no treatment) (Fig. 4D,E) . As with the L-DOPA model, we did not observe any protection from peroxide-induced loss with the S65A mutant (S65A: 54.1 ± 2.4% parkin remaining, N = 5; p = 0.84 vs. WT) (Fig. 4E ). Based on these results, it appears that parkin's association with phospho-Ub is critical, and fully accounts for, its degradation following exposure to hydrogen peroxide......
Document: 86.4 ± 5.4% parkin remaining, N = 5, p = 0.2 vs. no treatment) (Fig. 4D,E) . As with the L-DOPA model, we did not observe any protection from peroxide-induced loss with the S65A mutant (S65A: 54.1 ± 2.4% parkin remaining, N = 5; p = 0.84 vs. WT) (Fig. 4E ). Based on these results, it appears that parkin's association with phospho-Ub is critical, and fully accounts for, its degradation following exposure to hydrogen peroxide.
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