Author: Anniina Vihervaara; Dig Bijay Mahat; Samu V. Himanen; Malin A.H. Blom; John T. Lis; Lea Sistonen
Title: Stress-Induced Transcriptional Memory Accelerates Promoter-Proximal Pause-Release and Decelerates Termination over Mitotic Divisions Document date: 2019_3_14
ID: i3owd6b0_22
Snippet: Across their promoter-proximal ( Figure 2D ) and gene body ( Figure S2A ) regions, genes with 183! faster repression showed modestly lower Pol II density in heat-shocked preconditioned cells, 184! which demonstrates fewer Pol II molecules engaging into their transcription. This reduced 185! initiation could be indirectly caused by limited Pol II availability, as a larger fraction of Pol II 186! molecules were instantly engaged into transcription .....
Document: Across their promoter-proximal ( Figure 2D ) and gene body ( Figure S2A ) regions, genes with 183! faster repression showed modestly lower Pol II density in heat-shocked preconditioned cells, 184! which demonstrates fewer Pol II molecules engaging into their transcription. This reduced 185! initiation could be indirectly caused by limited Pol II availability, as a larger fraction of Pol II 186! molecules were instantly engaged into transcription of heat-activated genes. Taken together, our 187! results in singly heat shock-conditioned MEFs demonstrated that cells precisely remembered 188! their transcriptional identity throughout an acute heat shock, but that they also simultaneously 189! pre-wired an additional set of genes for a more rapid induction in the daughter cells. 190!
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