Author: Anniina Vihervaara; Dig Bijay Mahat; Samu V. Himanen; Malin A.H. Blom; John T. Lis; Lea Sistonen
Title: Stress-Induced Transcriptional Memory Accelerates Promoter-Proximal Pause-Release and Decelerates Termination over Mitotic Divisions Document date: 2019_3_14
ID: i3owd6b0_7
Snippet: Stress responses are evolutionarily conserved and robustly activated. Yet, severe stress can have 62! long-lasting consequences for an individual (Guan et al., 2002; Sailaja et al., 2012) and cause 63! physiological changes over several generations (Kaati et al., 2002; Wei et al., 2014; reviewed in 64! Heard and Martienssen, 2014) . On a cellular level, various stresses have been associated with 65! long-term changes in the chromatin state (Guan .....
Document: Stress responses are evolutionarily conserved and robustly activated. Yet, severe stress can have 62! long-lasting consequences for an individual (Guan et al., 2002; Sailaja et al., 2012) and cause 63! physiological changes over several generations (Kaati et al., 2002; Wei et al., 2014; reviewed in 64! Heard and Martienssen, 2014) . On a cellular level, various stresses have been associated with 65! long-term changes in the chromatin state (Guan et al., 2002; Tetievsky and Horowitch, 2010; 66! Sailaja et al., 2012; D'Urso et al., 2016; Lämke et al., 2016; reviewed in D'Urso and Brickner, 67! 2017) , and shown to confer thermotolerance against protein misfolding via increased chaperone 68! expression (Gerner and Schneider, 1975; Maytin et al., 1990; Yost and Lindquist, 1991) . To date, 69! however, stress-induced long-term changes in gene expression have been investigated from 70! steady-state RNA and protein expression, which do not quantify processes of nascent 71! transcription or reveal mechanistic control of Pol II. Besides chaperone expression, acquired 72! stress resistance is commonly assessed as improved cell viability. Since apoptosis is the final 73! stage of failed proteostasis and involves radical changes in cellular physiology, evaded cell death 74!
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