Structural basis to design multi-epitope vaccines against Novel Coronavirus 19 (COVID19) infection, the ongoing pandemic emergency: an in silico approach

Sukrit Srivastava; Sonia Verma; Mohit Kamthania; Rupinder Kaur; Ruchi Kiran Badyal; Ajay Kumar Saxena; Ho-Joon Shin; Kailash Pandey; Michael Kolbe

The epitopes showing overlapping regions in partial or complete were chosen for 217 detailed further studies. 218 10 The chosen CTL and HTL epitopes were analyzed for their molecular 219 interaction with their respective HLA allele binders. Moreover, the chosen CTL 220 epitopes were also analyzed for their molecular interaction with TAP (Transporter 221 associated with antigen processing) transporter cavity to observe their smooth 222 nine SARS-CoV-2 proteins (Bui et al., 2006) . T cells recognize the complex 305 between a specific major MHC molecule and a particular pathogen-derived 306 epitope. The given epitope will elicit a response only in an individual that express 307 an MHC molecule, which is capable of binding that particular epitope. This 308 denominated MHC restriction of T cell responses and the MHC polymorphism 309 provides the basis for population coverage study. The MHC types are expressed 310 author/funder. All rights reserved. No reuse allowed without permission.