Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2

Hualan Chen

One ferret from each virus-inoculated group developed fever and loss of appetite on days 10 and 12 p.i., respectively. To investigate whether these symptoms were caused by virus replication in the lower respiratory tract, we euthanized the two ferrets on day 13 p.i., and collected their organs for viral RNA detection. However, viral RNA was not detected in any other tissues or organs of either ferret, except for a low copy number (10 5.4 copies/g) in the turbinate of the ferret inoculated with CTan-H ( fig S2) . Pathological studies revealed severe lymphoplasmacytic perivasculitis and vasculitis, increased numbers of type II pneumocytes, macrophages, and neutrophils in the alveolar septa and alveolar lumen, and mild peribronchitis in the lungs of the two ferrets euthanized on day 13 p.i. (fig.S3 ).