Author: Lulin Zhou; Zubiao Niu; Xiaoyi Jiang; Zhengrong Zhang; You Zheng; Zhongyi Wang; Yichao Zhu; Lihua Gao; Xiaoning Wang; Qiang Sun
Title: Systemic analysis of tissue cells potentially vulnerable to SARS-CoV-2 infection by the protein-proofed single-cell RNA profiling of ACE2, TMPRSS2 and Furin proteases Document date: 2020_4_10
ID: 3btc31kj_20
Snippet: As compared with ACE2 and TMPRSS2, the expression of Furin protease is much less specific at both mRNA and protein levels, though some tissues, such as liver and lung, do express much higher than the others. Regarding the 5 tissues co-expressing TMPRSS2 and ACE2, thyroid gland and kidney appear to simultaneously express high level of Furin mRNA or protein ( Figure 1A , 1D, S1C and S1F)......
Document: As compared with ACE2 and TMPRSS2, the expression of Furin protease is much less specific at both mRNA and protein levels, though some tissues, such as liver and lung, do express much higher than the others. Regarding the 5 tissues co-expressing TMPRSS2 and ACE2, thyroid gland and kidney appear to simultaneously express high level of Furin mRNA or protein ( Figure 1A , 1D, S1C and S1F).
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