Author: Lulin Zhou; Zubiao Niu; Xiaoyi Jiang; Zhengrong Zhang; You Zheng; Zhongyi Wang; Yichao Zhu; Lihua Gao; Xiaoning Wang; Qiang Sun
Title: Systemic analysis of tissue cells potentially vulnerable to SARS-CoV-2 infection by the protein-proofed single-cell RNA profiling of ACE2, TMPRSS2 and Furin proteases Document date: 2020_4_10
ID: 3btc31kj_47
Snippet: In summary, we propose the pscRNA profiling a feasible way for gene expression analysis at both protein and mRNA levels. And through systemic analysis of 36 human tissues/organs by pscRNA profiling of ACE2, TMPRSS2 and Furin proteases, we propose a rank list of tissue cells potentially vulnerable to SARS-CoV-2 attack. For initial infection, ACE2-expression cells, with the co-expression of TMPRSS2 and Furin as a plus, in respiratory track are the .....
Document: In summary, we propose the pscRNA profiling a feasible way for gene expression analysis at both protein and mRNA levels. And through systemic analysis of 36 human tissues/organs by pscRNA profiling of ACE2, TMPRSS2 and Furin proteases, we propose a rank list of tissue cells potentially vulnerable to SARS-CoV-2 attack. For initial infection, ACE2-expression cells, with the co-expression of TMPRSS2 and Furin as a plus, in respiratory track are the primary targets. These cells include the known lung AT2 cells, and macrophages in author/funder. All rights reserved. No reuse allowed without permission.
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