Author: Aran Singanayagam; Su-Ling Loo; Maria Calderazzo; Lydia J Finney; Maria-Belen Trujillo Torralbo; Eteri Bakhsoliani; Jason Girkin; Punnam Veerati; Prabuddha S Pathinayake; Kristy S Nichol; Andrew Reid; Joseph Foottit; Sebastian L Johnston; Nathan W Bartlett; Patrick Mallia
Title: Anti-microbial immunity is impaired in COPD patients with frequent exacerbations Document date: 2019_5_9
ID: 72jzqm86_25
Snippet: We utilised a community-based cohort of COPD patients to evaluate anti-microbial immunity at baseline (stable-state) and during virus associated exacerbation. For baseline analyses of sputum cell mRNA (interferons (IFNs) and interferon-stimualated genes (ISGs)), 36 patients had sufficient sample for evaluation and, of these, 13 patients (36.1%) were classified as frequent exacerbators (clinical characteristics are shown in table 1). For baseline .....
Document: We utilised a community-based cohort of COPD patients to evaluate anti-microbial immunity at baseline (stable-state) and during virus associated exacerbation. For baseline analyses of sputum cell mRNA (interferons (IFNs) and interferon-stimualated genes (ISGs)), 36 patients had sufficient sample for evaluation and, of these, 13 patients (36.1%) were classified as frequent exacerbators (clinical characteristics are shown in table 1). For baseline analyses of sputum soluble mediators (CXCL10/IP10, MBL, SLPI and elafin proteins), samples from a total of 50 COPD patients (combined from the community cohort and from subjects recruited to experimental infection studies) were available, with 15 patients (30%) classified as frequent exacerbators (clinical characteristics are also shown in table 1 ).
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