Author: Aran Singanayagam; Su-Ling Loo; Maria Calderazzo; Lydia J Finney; Maria-Belen Trujillo Torralbo; Eteri Bakhsoliani; Jason Girkin; Punnam Veerati; Prabuddha S Pathinayake; Kristy S Nichol; Andrew Reid; Joseph Foottit; Sebastian L Johnston; Nathan W Bartlett; Patrick Mallia
Title: Anti-microbial immunity is impaired in COPD patients with frequent exacerbations Document date: 2019_5_9
ID: 72jzqm86_60
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/632372 doi: bioRxiv preprint Figure 4 : COPD patients with frequent exacerbations have increased bacterial loads during virus associated naturally occurring exacerbations. A cohort of patients with COPD were monitored prospectively. Patients were stratified according to exacerbation frequency in the preceding year with patients who experienced > .....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/632372 doi: bioRxiv preprint Figure 4 : COPD patients with frequent exacerbations have increased bacterial loads during virus associated naturally occurring exacerbations. A cohort of patients with COPD were monitored prospectively. Patients were stratified according to exacerbation frequency in the preceding year with patients who experienced > 2 exacerbation episodes classified as 'frequent'. Sputum samples were taken at presentation with exacerbation associated with positive virus detection and 2 weeks during exacerbation. Sputum bacterial loads were measured by 16S quantitative PCR at (a) baseline (b) exacerbation and (c) 2 weeks. Data shown as median (IQR) and analysed by Mann Whitney U test. *p<0.05. ns = non-significant.
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