The demyelinating agent cuprizone induces a male-specific reduction in binge eating in the binge-prone C57BL/6NJ strain

Richard K. Babbs; Jacob A. Beierle; Julia C. Kelliher; Rose Medeiros; Jeya Anandakumar; Anyaa Shah; Emily J. Yao; Melanie M. Chen; Camron D. Bryant

Here, we showed that two weeks of exposure to the cuprizone diet induced a significant 344 reduction in the level of MBP when assessed at nearly nine weeks after the beginning of cuprizone 345 without affecting MAG at the time of assessment, irrespective of Sex or Substrain (Fig.5) . MBP 346 is a major structural protein produced by oligodendrocytes and Schwan cells and redistributes to 347 the processes to initiate axon ensheathment, compaction, thickening, and adhesion (Han, following the beginning of cuprizone treatment as the process of remyelination ensued (Ludwin & 363 Sternberger, 1984) . It is also possible that there are brain region-specific changes in myelin-364 . CC-BY-NC-ND 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/865600 doi: bioRxiv preprint 15 associated proteins and that the striatum shows a different profile than, e.g., the corpus callosum 365 which is the hallmark tissue that is typically employed to assess the degree of cuprizone-induced 366