Selected article for: "host target and virus discovery"
Author: Nils C. Gassen; Jan Papies; Thomas Bajaj; Frederik Dethloff; Jackson Emanuel; Katja Weckmann; Daniel E. Heinz; Nicolas Heinemann; Martina Lennarz; Anja Richter; Daniela Niemeyer; Victor M. Corman; Patrick Giavalisco; Christian Drosten; Marcel A. Müller
Title: Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
  • Document date: 2020_4_15
    • ID: k1retwa4_1
    Snippet: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an acute threat to public health 22 and the world economy, especially because no approved specific drugs or vaccines are available. Compound-based targeting of cellular proteins that are essential for the virus life cycle has led to the 50 discovery of broadly reactive drugs against a range of CoVs (3-6). As virus propagation strongly 51 depends on energy and catabolic substrates .....
    Document: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an acute threat to public health 22 and the world economy, especially because no approved specific drugs or vaccines are available. Compound-based targeting of cellular proteins that are essential for the virus life cycle has led to the 50 discovery of broadly reactive drugs against a range of CoVs (3-6). As virus propagation strongly 51 depends on energy and catabolic substrates of host cells, drug target identification should consider 52 the metabolism of infected cells (3). Autophagy, a highly conserved cytosolic degradation process of 53 long-lived proteins, lipids, and organelles in eukaryotic cells, is tightly controlled by metabolism (7, 8).

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