Selected article for: "cov virus and MERS cov"
Author: Nils C. Gassen; Jan Papies; Thomas Bajaj; Frederik Dethloff; Jackson Emanuel; Katja Weckmann; Daniel E. Heinz; Nicolas Heinemann; Martina Lennarz; Anja Richter; Daniela Niemeyer; Victor M. Corman; Patrick Giavalisco; Christian Drosten; Marcel A. Müller
Title: Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
  • Document date: 2020_4_15
    • ID: k1retwa4_3
    Snippet: During autophagy, intracellular macromolecules are recycled by incorporation into LC3B-lipidated 55 autophagosomes (AP) and degradation into their monomers, such as fatty and amino acids, after 56 fusion with low pH lysosomes (9). In the case of highly pathogenic Middle East respiratory syndrome 57 (MERS)-CoV, we recently showed that autophagy is limited by a virus-induced AKT1-dependent 58 activation of the E3-ligase S-phase kinase-associated pr.....
    Document: During autophagy, intracellular macromolecules are recycled by incorporation into LC3B-lipidated 55 autophagosomes (AP) and degradation into their monomers, such as fatty and amino acids, after 56 fusion with low pH lysosomes (9). In the case of highly pathogenic Middle East respiratory syndrome 57 (MERS)-CoV, we recently showed that autophagy is limited by a virus-induced AKT1-dependent 58 activation of the E3-ligase S-phase kinase-associated protein 2 (SKP2), which targets the key autophagy 59 initiating protein Beclin-1 (BECN1) for proteasomal degradation (10). Congruently, inhibition of SKP2 60 by different compounds, including clinically approved drugs, stabilized BECN1 and limited MERS-CoV 61 propagation, indicating that autophagy-inducing compounds hold promise for evaluation as antiviral 62 drugs. This paper investigates the impact of SARS-CoV-2 infection on cell metabolism and the 63 downstream effects on autophagy, thereby identifying multiple targets for the application of approved 64 drugs and the development of new antiviral therapies.

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