Author: Jason W. Westerbeck; Carolyn E. Machamer
Title: The Infectious Bronchitis Virus Coronavirus Envelope Protein Alters Golgi pH to Protect Spike Protein and Promote Release of Infectious Virus Document date: 2018_10_11
ID: amg5dice_3
Snippet: To understand CoV E at a cell biological level, a recombinant virus system was used to The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/440628 doi: bioRxiv preprint 5 IBV E or EG3 reduces trafficking rates of both membrane and secretory cargo (23). Given that release of infectious IBV EG3 is reduced, it was surprising that wild-type E protein reduced cargo trafficking. It was .....
Document: To understand CoV E at a cell biological level, a recombinant virus system was used to The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/440628 doi: bioRxiv preprint 5 IBV E or EG3 reduces trafficking rates of both membrane and secretory cargo (23). Given that release of infectious IBV EG3 is reduced, it was surprising that wild-type E protein reduced cargo trafficking. It was hypothesized that since the HD was required, alteration of the lumen by E ion channel activity was required for maintaining intact virus, and the reduced rates of trafficking were an acceptable compromise for the virus.
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