Selected article for: "gene expression and mrna expression"
Author: Lea Gaucherand; Brittany K. Porter; Summer K. Schmaling; Christopher Harley Rycroft; Yuzo Kevorkian; Craig McCormick; Denys A. Khaperskyy; Marta Maria Gaglia
Title: The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression
  • Document date: 2018_10_14
    • ID: 8k7w467p_27
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. Interestingly, we did not isolate many core components of transcription or mRNA processing 433 machinery. PA-X appears to interact mostly with factors that are considered regulators of 434 alternative splicing (PUF60, RBM39, HNRNPK), or connect splicing with adenylation and 435 enhance poly(A) site choice (CPSF5/NUDT21, CPSF6). It will be interesting to det.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. Interestingly, we did not isolate many core components of transcription or mRNA processing 433 machinery. PA-X appears to interact mostly with factors that are considered regulators of 434 alternative splicing (PUF60, RBM39, HNRNPK), or connect splicing with adenylation and 435 enhance poly(A) site choice (CPSF5/NUDT21, CPSF6). It will be interesting to determine how 436 these proteins are involved in PA-X activity. Particularly, since these proteins do not regulate the 437 processing of all mRNAs in the cell to the same extent, interactions with these proteins could 438 offer PA-X an additional mechanism for target discrimination. Another interesting question is 439 whether these associations compromise the normal activity of the cellular proteins. We did not 440 find dramatic changes in the host splicing pattern in our dataset (not shown), but we may have 441 missed some subtle changes. 442 443 It is interesting that both PA-X and the well known influenza host shutoff factor NS1 interact 444 with nuclear mRNA processing machinery to control gene expression (Nemeroff et al., 1998) . 445

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