Author: Alisher M Kariev; Michael E Green
Title: The Role of Proton Transport in Gating Current in a Voltage Gated Ion Channel, as Shown by Quantum Calculations Document date: 2018_7_19
ID: cyxdy7hg_29
Snippet: K + CONCENTRATION DEPENDENCE OF CONDUCTION: The dependence of the conductance of a KcsA channel on the concentration of K + ion is similar to that of other K + channels. It was measured by LeMasurier et al (102) ; the data from that paper has been replotted by Kariev and Green as Fig. 3 , using -RT log [K + ] = ΔG (40) . This shows the conductivity is proportional to the free energy of the [K + ] ion, which is consistent with the existence of a .....
Document: K + CONCENTRATION DEPENDENCE OF CONDUCTION: The dependence of the conductance of a KcsA channel on the concentration of K + ion is similar to that of other K + channels. It was measured by LeMasurier et al (102) ; the data from that paper has been replotted by Kariev and Green as Fig. 3 , using -RT log [K + ] = ΔG (40) . This shows the conductivity is proportional to the free energy of the [K + ] ion, which is consistent with the existence of a single barrier for conduction of the ion. The free energy is given relative to the low concentration, hence is shown as ΔΔG. The conductivity is σ, and is shown as relative conductance. This would be consistent with a barrier at the entrance to the pore, if the conductivity measures the effective concentration of the K + in the pore, and the free energy is proportional, as just The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/371914 doi: bioRxiv preprint (40) .
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