Author: Brian D Quinlan; Huihui Mou; Lizhou Zhang; Yan Gao; Wenhui He; Amrita Ojha; Mark S Parcells; Guangxiang Luo; Wenhui Li; Guocai Zhong; Hyeryun Choe; Michael Farzan
Title: The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement Document date: 2020_4_12
ID: fnguelau_1
Snippet: Coronaviruses are enveloped single-stranded, positive-strand RNA viruses of the family Corornaviridae (Cui et al., 2019) . They divide into four main subgroups: α, β, γ, and δ. At least seven coronaviruses infect humans: the α-coronaviruses HCoV-229E and HCoV-OC43, and the β-coronaviruses SARS-CoV (SARS-CoV-1), HCoV-NL63, CoV-HKU1, MERS-CoV, and the recently described SARS-CoV-2 (nCoV-19), a β-coronavirus closely related to human SARS-CoV-.....
Document: Coronaviruses are enveloped single-stranded, positive-strand RNA viruses of the family Corornaviridae (Cui et al., 2019) . They divide into four main subgroups: α, β, γ, and δ. At least seven coronaviruses infect humans: the α-coronaviruses HCoV-229E and HCoV-OC43, and the β-coronaviruses SARS-CoV (SARS-CoV-1), HCoV-NL63, CoV-HKU1, MERS-CoV, and the recently described SARS-CoV-2 (nCoV-19), a β-coronavirus closely related to human SARS-CoV-1 (79.0% nucleotide identity) and to SARS-CoV-like variants isolated in bats, including bat-SL-CoV-RaTG13 (96.2% nucleotide identity) (Lu et al., 2020; Menachery et al., 2015; Zhou et al., 2020) . SARS-CoV-2 infection causes mild flu-like symptoms in many patients, but in many cases develops into an acute pulmonary syndrome (Chen et al., 2020; Zhou et al., 2020) . SARS-CoV-1 causes severe acute respiratory syndrome (SARS), whereas disease associated with SARS-CoV-2 has been named COVID-19.
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