Author: Yan Li; Jinyong Zhang; Ning Wang; Haibo Li; Yun Shi; Gang Guo; Kaiyun Liu; Hao Zeng; Quanming Zou
Title: Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening Document date: 2020_1_29
ID: iu2ziccm_42
Snippet: Bictegravir. Further, molecule Prulifloxacin, Tegobuvir and Bictegravir are preferable to Nelfinaviras confirmed by affinity and physical-chemical properties analysis using SeeSAR. Based on the pockets' functions of target protein, it suggested that these molecules should possess the abilities to block the active sites or interrupt the dimer formation of viral protein. Therefore, they may sever as promising candidates for drug repurpose and devel.....
Document: Bictegravir. Further, molecule Prulifloxacin, Tegobuvir and Bictegravir are preferable to Nelfinaviras confirmed by affinity and physical-chemical properties analysis using SeeSAR. Based on the pockets' functions of target protein, it suggested that these molecules should possess the abilities to block the active sites or interrupt the dimer formation of viral protein. Therefore, they may sever as promising candidates for drug repurpose and development against 2019-nCoV. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.01.28.922922 doi: bioRxiv preprint
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