Author: Antonio Gonçalves; Julie Bertrand; Ruian Ke; Emmanuelle Comets; Xavier de Lamballerie; Denis Malvy; Andrés Pizzorno; Olivier Terrier; Manuel Rosa Calatrava; France Mentré; Patrick Smith; Alan S Perelson; Jérémie Guedj
Title: Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load Document date: 2020_4_7
ID: n6l2804j_26
Snippet: Overall our results emphasize that the PK/PD properties of lopinavir/ritonavir, IFN-β-1a 194 and hydroxychloroquine make them unlikely to have a dramatic impact on viral load kinetics 195 in the nasopharynx if they are administered after symptom onset. Given this, it is possible that 196 continued viral replication in the presence of drug will select for drug resistant mutations as 197 has been seen with other RNA viruses [7], although coronavir.....
Document: Overall our results emphasize that the PK/PD properties of lopinavir/ritonavir, IFN-β-1a 194 and hydroxychloroquine make them unlikely to have a dramatic impact on viral load kinetics 195 in the nasopharynx if they are administered after symptom onset. Given this, it is possible that 196 continued viral replication in the presence of drug will select for drug resistant mutations as 197 has been seen with other RNA viruses [7], although coronaviruses are unusual in that they 198 All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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