Author: Dorothea Bestle; Miriam Ruth Heindl; Hannah Limburg; Thuy Van Lam van; Oliver Pilgram; Hong Moulton; David A. Stein; Kornelia Hardes; Markus Eickmann; Olga Dolnik; Cornelius Rohde; Stephan Becker; Hans-Dieter Klenk; Wolfgang Garten; Torsten Steinmetzer; Eva Böttcher-Friebertshäuser
Title: TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets Document date: 2020_4_15
ID: anedg12x_24
Snippet: we could experimentally demonstrate for the first time that furin only activates the S1/S2 site, The S protein of IBV strain Beaudette contains multibasic motifs at the S1/S2 and S2' site 435 substrates of the S1/S2 and S2' site of the IBV Beaudette S protein were efficiently cleaved 439 by furin (Fig. 2B and Fig. S2B) . However, the advantage of furin-cleavable multibasic motifs 440 at the S1/S2 and/or S2' site for multicycle replication, cellul.....
Document: we could experimentally demonstrate for the first time that furin only activates the S1/S2 site, The S protein of IBV strain Beaudette contains multibasic motifs at the S1/S2 and S2' site 435 substrates of the S1/S2 and S2' site of the IBV Beaudette S protein were efficiently cleaved 439 by furin (Fig. 2B and Fig. S2B) . However, the advantage of furin-cleavable multibasic motifs 440 at the S1/S2 and/or S2' site for multicycle replication, cellular tropism and pathogenicity of 441 HCoVs remains to be determined. HCoV-OC43 and HCoV-HKU1 possess a furin cleavage 442 motif at the S1/S2 site. In contrast, the S proteins of the 2002 SARS-CoV, HCoV-229E and 443
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