Author: K. Reddisiva Prasanth; Minato Hirano; W. Samuel Fagg; Eileen T. McAnarney; Chao Shan; Xuping Xie; Adam Hage; Colette A. Pietzsch; Alexander Bukreyev; Ricardo Rajsbaum; Pei-Yong Shi; Mark T. Bedford; Shelton S. Bradrick; Vineet Menachery; Mariano A. Garcia-Blanco
Title: Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses Document date: 2020_3_27
ID: a0xfb9l4_10
Snippet: Most important in the context of the COVID-19 pandemic, four betacoronaviruses, of the Coronaviridae family, SARS-CoV, SARS-CoV-2, MERS-CoV, and SCH1014-CoV, a bat coronavirus, were significantly crippled by TOP3B KO (Fig 2C) . These results indicated that TOP3B is a host factor essential for efficient replication of a diverse group of (+) ss RNA viruses......
Document: Most important in the context of the COVID-19 pandemic, four betacoronaviruses, of the Coronaviridae family, SARS-CoV, SARS-CoV-2, MERS-CoV, and SCH1014-CoV, a bat coronavirus, were significantly crippled by TOP3B KO (Fig 2C) . These results indicated that TOP3B is a host factor essential for efficient replication of a diverse group of (+) ss RNA viruses.
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