Selected article for: "International license and valuable information"
Author: Lin Lv; Xiaoqing Xie; Qiyu Gong; Ru Feng; Xiaokui Guo; Bing Su; Lei Chen
Title: Transcriptional Difference between SARS-COV-2 and other Human Coronaviruses Revealed by Sub-genomic RNA Profiling
  • Document date: 2020_4_18
    • ID: 6tytbgpq_4
    Snippet: An interesting observation is that all accessory genes were down-regulated in vitro. This could make 130 biological sense as in defenseless cultured cells, viruses devote more resource into reproduction, while to 131 cope with more host defense in vivo, accessory genes have to more important roles to play. This also 132 suggested there was intricate expression regulation mechanism at work here, even for this small 30 Kb 133 genome. 134 Finally, t.....
    Document: An interesting observation is that all accessory genes were down-regulated in vitro. This could make 130 biological sense as in defenseless cultured cells, viruses devote more resource into reproduction, while to 131 cope with more host defense in vivo, accessory genes have to more important roles to play. This also 132 suggested there was intricate expression regulation mechanism at work here, even for this small 30 Kb 133 genome. 134 Finally, there are more than just viral information within this type of meta-transcriptomic data. Host 164 RNA and RNA from other microbes were also there, though not optimally captured. In a time of urgent 165 need, these valuable information should not be wasted, and could be made more useful if more 166 accompanying clinical information could be shared. Most GISAID entries for SARS-CoV-2 has a meta-167 transcriptomic dataset behind it and currently GISAID entries far out-numbered the raw reads entries in say 168 SRA. Sharing these information will greatly help researchers study this virus and ultimately curb it. 169 . CC-BY-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.16.043224 doi: bioRxiv preprint

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