Translational adaptation of human viruses to the tissues they infect

Xavier Hernandez-Alias; Martin Schaefer; Luis Serrano

In order to understand the main factors driving differences between viral RCU, we used three internal clustering indexes that assess how similar each virus is to a certain group compared to other groups. Taking the average RCU over each of the 564 viral proteomes, we applied . CC-BY 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.06.027557 doi: bioRxiv preprint this framework to assess the grouping performance of six different viral features: tropism, type of genetic material, family, genus, Baltimore category, and a sequence-based classification by Aiewsakun and Simmonds (2018) . In such analysis, the tropism leads the best classification of viral RCUs, followed by the viral genetic type (Fig. 1B) . On the other hand, classical and sequence-based phylogenetic classifications show poor clustering performances.