Selected article for: "acei effect and lung injury"
Author: Daniel Bean; Zeljko Kraljevic; Thomas Searle; Rebecca Bendayan; Andrew Pickles; Amos Folarin; Lukasz Roguski; Kawsar Noor; Anthony Shek; Kevin o'gallagher; Rosita Zakeri; Ajay Shah; James Teo; Richard JB Dobson
Title: Treatment with ACE-inhibitors is associated with less severe disease with SARS-Covid-19 infection in a multi-site UK acute Hospital Trust
  • Document date: 2020_4_11
    • ID: 60wcvkbn_1
    Snippet: Early data from China during the SARS-Cov2 pandemic suggest that patients with hypertension or diabetes have an increased risk of severe COVID-19 disease. 1 It has been hypothesized that treatment with ACE-inhibitors (ACEi) or angiotensin receptor blockers (ARB) in such patients may increase the expression of ACE2, the receptor for SARS-Cov2 binding and entry into cells. 1, 2 However, reduced activation of the renin angiotensin system (RAS) and/o.....
    Document: Early data from China during the SARS-Cov2 pandemic suggest that patients with hypertension or diabetes have an increased risk of severe COVID-19 disease. 1 It has been hypothesized that treatment with ACE-inhibitors (ACEi) or angiotensin receptor blockers (ARB) in such patients may increase the expression of ACE2, the receptor for SARS-Cov2 binding and entry into cells. 1, 2 However, reduced activation of the renin angiotensin system (RAS) and/or increased levels of ACE2 may be protective during severe lung injury. 3 The effect of ACEi and ARB during infection with SARS-CoV-2 is therefore controversial but needs urgent clarification. [4] [5] [6] [7] We tested for association between treatment with ACEi or ARB and disease severity in the first 205 patients with COVID-19 disease admitted to a multi-site acute NHS Trust in the United Kingdom (King's College Hospital NHS Foundation Trust). We used an informatics pipeline to allow rapid evaluation of disease concepts during the rapidly evolving pandemic.

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