Author: Satria P. Sajuthi; Peter DeFord; Nathan D. Jackson; Michael T. Montgomery; Jamie L. Everman; Cydney L. Rios; Elmar Pruesse; James D. Nolin; Elizabeth G. Plender; Michael E. Wechsler; Angel CY Mak; Celeste Eng; Sandra Salazar; Vivian Medina; Eric M. Wohlford; Scott Huntsman; Deborah A. Nickerson; Soren Germer; Michael C. Zody; Gonçalo Abecasis; Hyun Min Kang; Kenneth M. Rice; Rajesh Kumar; Sam Oh; Jose Rodriguez-Santana; Esteban G. Burchard; Max A. Seibold
Title: Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium Document date: 2020_4_10
ID: mj8ebo7i_18
Snippet: In summary, our data suggests that the strongest determinants of airway ACE2 and 522 TMPRSS2 expression are T2 inflammation and viral-induced interferon inflammation, 523 with limited but noteworthy influence from genetic variation. Whether these factors drive 524 better or worse clinical outcomes remains to be determined, but closely watching 525 individuals with these airway endotypes in the clinical management of COVID-19 526 illnesses would b.....
Document: In summary, our data suggests that the strongest determinants of airway ACE2 and 522 TMPRSS2 expression are T2 inflammation and viral-induced interferon inflammation, 523 with limited but noteworthy influence from genetic variation. Whether these factors drive 524 better or worse clinical outcomes remains to be determined, but closely watching 525 individuals with these airway endotypes in the clinical management of COVID-19 526 illnesses would be prudent. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.09.034454 doi: bioRxiv preprint Health (NJH) live cell core, which is an institutional review board-approved study (HS-559 2240) for the collection of tissues from consented patients for researchers at NJH. 560 561
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