Author: Sean M. Boyles; Carla N. Mavian; Esteban Finol; Maria Ukhanova; Caroline J. Stephenson; Gabriela Hamerlinck; Seokyoung Kang; Caleb Baumgartner; Mary Geesey; Israel Stinton; Kate Williams; Derrick K. Mathias; Mattia Prosperi; Volker Mai; Marco Salemi; Eva A. Buckner; John A. Lednicky; Adam R. Rivers; Rhoel R. Dinglasan
Title: Under-the-radar dengue virus infections in natural populations of Aedes aegypti mosquitoes Document date: 2020_1_25
ID: 9d8k7b23_10
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.01. 24 the 2K peptide, NS4B, and NS5) (Fig. 4a) . The protein-coding regions of Manatee DENV4 215 were compared to four Haitian DENV4 genomes from 1994-2015 and a 1981 Senegalese 216 DENV4 genome. These were analyzed for all amino acid substitutions between strains, and a 217 dN/dS analysis was conducted comparing the Senegalese DENV4 genome.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.01. 24 the 2K peptide, NS4B, and NS5) (Fig. 4a) . The protein-coding regions of Manatee DENV4 215 were compared to four Haitian DENV4 genomes from 1994-2015 and a 1981 Senegalese 216 DENV4 genome. These were analyzed for all amino acid substitutions between strains, and a 217 dN/dS analysis was conducted comparing the Senegalese DENV4 genome with Manatee 218 DENV4 ( Fig. 4a and Table S2 ). The highest proportions of amino acid substitution were seen 219 in NS2A and the 2K peptide; simultaneously, the highest dN/dS values occurred for the NS2A 220 gene, to a point of weak positive selection (dN/dS > 1) that covered a V1238T mutation 221 discussed further herein. We then calculated dN/dS ratios for DENV4 altogether, genotype II, 222 genotype IIa, and genotype IIb with all sequences available, as well as within the Haiti-Florida 223 clade and the Haiti-Florida-Puerto-Rico clades (Fig. 4b) . Purifying selection, which occurs 224 when non-synonymous mutations are deleterious, dominated, but we found weaker purifying 225 selection in NS2A and 2K peptide genes, correlating to the Manatee-to-Senegal dN/dS 226 analysis conducted previously. Values of dN/dS for these genes increased relative to those for 227 flanking genes for genotype IIb and Caribbean/Florida-specific groups as well (Fig. 4b) .
Search related documents:
Co phrase search for related documents- amino acid and dN dS ratio: 1, 2, 3, 4, 5, 6, 7, 8, 9
- amino acid and dN dS value: 1
- amino acid and flank gene: 1
- amino acid and gene increase: 1, 2, 3
- amino acid and high proportion: 1, 2, 3, 4, 5, 6, 7, 8, 9
- amino acid and non synonymous mutation: 1, 2, 3, 4, 5, 6, 7, 8
- amino acid and peptide gene: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- amino acid and positive selection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- amino acid and protein code: 1, 2, 3, 4, 5, 6
- amino acid and strain amino acid substitution: 1, 2, 3, 4, 5
- amino acid substitution and available sequence: 1, 2
- amino acid substitution and flank gene: 1
- amino acid substitution and non synonymous mutation: 1, 2
- amino acid substitution and positive selection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- amino acid substitution and strain amino acid substitution: 1, 2, 3, 4, 5
- available sequence and peptide gene: 1
- available sequence and positive selection: 1, 2, 3
- dN dS ratio and genotype IIa: 1
- dN dS ratio and positive selection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
Co phrase search for related documents, hyperlinks ordered by date