Author: Yasunori Watanabe; Zachary T. Berndsen; Jayna Raghwani; Gemma E. Seabright; Joel D. Allen; Jason S. McLellan; Ian A. Wilson; Thomas A. Bowden; Andrew B. Ward; Max Crispin
Title: Vulnerabilities in coronavirus glycan shields despite extensive glycosylation Document date: 2020_2_21
ID: bnnt05fn_20
Snippet: Left panel: Sharpened 3.2â„«-resolution C3-symmetric cryo-EM map of SARS S 2P ectodomain 54 visualized at a high contour level with disordered S1 receptor binding and N-terminal domains extending out from the central core. Middle panel: Low-pass filtered cryo-EM map of the glycoprotein visualised at a low contour level along with a simulated peptide-only map overlaid. Right panel: SPARX 3D variability map 53 . (B) Same as in (A) but for HIV-1 Env.....
Document: Left panel: Sharpened 3.2â„«-resolution C3-symmetric cryo-EM map of SARS S 2P ectodomain 54 visualized at a high contour level with disordered S1 receptor binding and N-terminal domains extending out from the central core. Middle panel: Low-pass filtered cryo-EM map of the glycoprotein visualised at a low contour level along with a simulated peptide-only map overlaid. Right panel: SPARX 3D variability map 53 . (B) Same as in (A) but for HIV-1 Env BG505 SOSIP.664 construct in complex with 3 copies of RM20A3 base-specific Fabs 53 .
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