Author: Dong, Peng; Ju, Xiangwu; Yan, Yiwu; Zhang, Siya; Cai, Menghua; Wang, Huaishan; Chen, Hui; Hu, Yu; Cui, Lianxian; Zhang, Jianmin; He, Wei
Title: ?d T Cells Provide Protective Function in Highly Pathogenic Avian H5N1 Influenza A Virus Infection Document date: 2018_12_4
ID: 0frb01wq_40
Snippet: TCR γδ and NKG2D are two most important receptors on the surface of γδ T cells to initiate γδ T cell-mediated immune response (26, 27) . However, the treatment of γδ T cells with TCR γδ and NKG2D mAbs could not block HAF-induced γδ T cell activation ( Figure 6A) . Then we applied several pharmacological inhibitors to explore the signal transduction pathways involved in HA-induced γδ T cell activation. HA-induced γδ T cell activati.....
Document: TCR γδ and NKG2D are two most important receptors on the surface of γδ T cells to initiate γδ T cell-mediated immune response (26, 27) . However, the treatment of γδ T cells with TCR γδ and NKG2D mAbs could not block HAF-induced γδ T cell activation ( Figure 6A) . Then we applied several pharmacological inhibitors to explore the signal transduction pathways involved in HA-induced γδ T cell activation. HA-induced γδ T cell activation could be inhibited by the phosphatase calcineurin inhibitor CsA but not by the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002 (Figure 6B) . These results reveal that calcineurin-nuclear factor of activated T cell cytoplasmic (NFATc) pathway plays a critical role in HA-induced γδ T cell activation.
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