Author: Dong, Peng; Ju, Xiangwu; Yan, Yiwu; Zhang, Siya; Cai, Menghua; Wang, Huaishan; Chen, Hui; Hu, Yu; Cui, Lianxian; Zhang, Jianmin; He, Wei
Title: ?d T Cells Provide Protective Function in Highly Pathogenic Avian H5N1 Influenza A Virus Infection Document date: 2018_12_4
ID: 0frb01wq_51
Snippet: In summary, our study demonstrates for the first time that γδ T cells play an important role in the defense against HPAI H5N1 virus infection. γδ T cells could be directly activated by HPAI H5N1 viruses through natural trimers of HA proteins; this ability was dependent on sialic acid receptors on the surface of γδ T cells and on the HA glycosylation. Furthermore, HAinduced γδ T cell activation can be inhibited by CsA but not by wortmannin.....
Document: In summary, our study demonstrates for the first time that γδ T cells play an important role in the defense against HPAI H5N1 virus infection. γδ T cells could be directly activated by HPAI H5N1 viruses through natural trimers of HA proteins; this ability was dependent on sialic acid receptors on the surface of γδ T cells and on the HA glycosylation. Furthermore, HAinduced γδ T cell activation can be inhibited by CsA but not by wortmannin or LY294002. Our results provide new insights about the immunoprotective role of γδ T cells in the defense against HPAI H5N1 virus infection and provide a novel strategy for controlling influenza virus infection in the future.
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