Selected article for: "cleavage site and gene sequence"
Author: Ping Liu; Jing-Zhe Jiang; Xiu-Feng Wan; Yan Hua; Xiaohu Wang; Fanghui Hou; Jing Chen; Jiejian Zou; Jinping Chen
Title: Are pangolins the intermediate host of the 2019 novel coronavirus (2019-nCoV) ?
  • Document date: 2020_2_20
    • ID: 2inlyd0t_15
    Snippet: The nucleotide sequence identities of the surface glycoprotein Spike (S) protein genes between pangolin-CoV-2020 and 2019-nCoV was 82.21%, and the Bat-CoV-RaTG13 and 2019-nCoV shared the highest sequence identity of 92.59% (Table 1 ). There was a low similarity of 72.63% between the S genes of pangolin-CoV-2020 and SARS-CoV. Nucleotide sequence analyses suggested the S gene was relatively more genetic diverse in the S1 region than the S2 region (.....
    Document: The nucleotide sequence identities of the surface glycoprotein Spike (S) protein genes between pangolin-CoV-2020 and 2019-nCoV was 82.21%, and the Bat-CoV-RaTG13 and 2019-nCoV shared the highest sequence identity of 92.59% (Table 1 ). There was a low similarity of 72.63% between the S genes of pangolin-CoV-2020 and SARS-CoV. Nucleotide sequence analyses suggested the S gene was relatively more genetic diverse in the S1 region than the S2 region ( Figure 2a ). Furthermore, the S proteins of pangolin-CoV-2020 and 2019-nCoV had a sequence identity of 89.78% (Table 2) , sharing a very conserved receptor binding motif (RBM) ( Figure S1 ), which is more conserved than in Bat-CoV-RaTG13. These results support that pangolin-CoV-2020 and 2019-nCoV, and SARS-CoV could all share the same receptor ACE2. The presence of highly identical RBMs in pangolin-CoV-2020 and 2019-nCoV means that this motif was likely already present in the virus before jumping to humans. However, it is interesting that both pangolin-CoV-2020 and Bat-CoV-RaTG13 lack a S1/S2 cleavage site (~680-690 aa) whereas 2019-nCoV possess ( Figure S1 ).

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